ABSTRACT

Cholinergic system The clinical evidence pointing towards involvement of the cholinergic system in sexual function and dysfunction is based largely on the side-effects of psychotropic drugs possessing potent anticholinergic activity, notably tricyclic antidepressants (TCAs). Erectile difficulties and orgasmic inhibition are the main side-effects attributable to antagonism of the cholinergic system. These clinical observations are supported by physiological findings indicating cholinergic innervation of the human corpora cavernosa and the presence of cholinergic receptors in penile tissue. However, central cholinergic transmission may also play a role in modulating sexual function, and it is suspected that central muscarinic receptors may mediate arousal.2