ABSTRACT
This chapter addresses the male reproductive system as a target of carcinogenesis. The male reproductive organs include the testis with its efferent duct system, in cluding the epididymis, the accessory sex glands, the preputial gland, and the penis. Although of these reproductive tissues the preputial gland is the most fre quent site of tumor formation in carcinogenesis bioassays (1,2), the discussion on target-organ carcinogenesis in this chapter focuses primarily on the testis and the prostate, because more information is available about these sites than about the other tissues. The preputial gland, the testicular efferent duct system, and the male accessory sex glands other than the prostate are discussed only briefly. The penis is not included, because it has never been reported as a target of chemical carcinogen esis, and in humans penile cancer probably has a predominantly viral etiology (3), which is outside the scope of this chapter.
