ABSTRACT
Tumors of the hematopoietic system occur spontaneously in most animal species, including humans. In an experimental animal setting they are known to be induced by a variety of agents in many different treatment schedules and are one of the earliest model systems in carcinogenesis research. Many experimental studies use the mouse as a model system. Tumors of the hematopoietic system are known to be induced by viruses, radiation, and chemicals. In addition, the pathogenesis of these tumors is influenced by a host of other factors, such as nutrition and immune status. In this chapter we discuss the classification of hematopoietic tumors, then focus our attention on the various agents, followed by a section on the pathogenesis of these tumors.
