ABSTRACT
INTRODUCTION Cells in culture provide an in vitro alternative in the assessment of neurotoxicity, and increased use has been suggested.1,2 This type of test system has several advantages, including the potential to screen relatively large numbers of chemicals in a relatively short period of time and with considerably less cost than if such screening were done in animal models. In addition to increased efficiency associated with toxicity studies, data could be obtained from human cells, and it is the human that is the species of interest in risk assessment. Currently, extrapolation from animal studies is needed, and species differences can be notable.
