ABSTRACT

Reversed-phase high-performance liquid chromatography (RP-HPLC) has been widely used as the standard for the high-throughput analysis of soluble polar compounds. In RP-HPLC, separation of polar compounds is achieved giving an elution order based on increasing hydrophobicity. Although a powerful technique, RP-HPLC is not ideal for highly hydrophilic compounds as they are poorly retained and are

19.1 Introduction ..................................................................................................445 19.2 Experimental Section ...................................................................................447