ABSTRACT

Microarrays have been introduced as powerful tools able to screen a large number of genes in an efficient manner.1 The typical result of a microarray

to generate hypotheses, and locate effects on many, perhaps apparently unrelated pathways. This is a typical hypothesis generating experiment. For this purpose, it is best to use comprehensive microarrays that represent as many genes of an organism as possible. Currently, such arrays include tens of thousands of genes. For example, the HGU133 (A+B) set from Affymetrix, Inc., contains 44,928 probes that represent 42,676 unique sequences from GenBank database, corresponding to 30,264 UniGene clusters.