ABSTRACT
Chemotherapy remains a critical component for the treatment of cancer, the estimated cause of one in eight deaths worldwide.1 Historically, natural products have been excellent sources of chemotherapeutics providing a foundation for anticancer drug discovery and development.2 However, the increasing incidence of drug resistance3,4 along with cumulative side effects of certain chemotherapies4,5 warrants the continued and expanded discovery of new therapeutics. Fortunately, signiœcant progress has been made on several fronts that have allowed the implementation of new strategies for structural diversiœcation. Combinatorial biosynthesis is one such strategy aimed at harnessing the inherent power of microbial genetics and expedient biosynthetic machineries en route to natural products with anticancer potential.
