ABSTRACT

Although the increasingly precise techniques of analytical chemistry allow us to identify and to quantify, in all physical or biological matrices, an increasing number of xenobiotics and their metabolites, they do not provide access to all the toxic molecules of interest. Moreover, these measures supply no information about toxic

3.1 Introduction .................................................................................................... 49 3.2 Tolerance and Choice of Biological Models for Bioassays ............................. 51

3.2.1 Interspecific Variability of Tolerance ................................................. 51 3.2.2 Intraspecific Variability of Tolerance .................................................54