ABSTRACT

Our living environment is continuously changing, and failure to cope with environmental ©uctuations such as mental challenge, muscular work, temperature shift, and tissue hypoxia is the primary cause of illness and death. Successful coping and adaptation against unpredictable daily challenges ensure continuation of our well-being and survival. Baseline plasma dehydroepiandrosterone sulfate (DHEAS) concentration has been found to closely associate with human longevity and ‰tness and is known to decline with advancing age. In this view, we performed a series of research on humans to examine the role of DHEAS in postchallenged recovery. Our recent ‰ndings suggest that DHEAS is consumed during recovery against external challenge.