ABSTRACT
The decline in endogenous dehydroepiandrosterone (DHEA) production associated with aging may contribute to an array of physiological changes that are sex hormone dependent, including the loss of bone mass. Accordingly, increasing circulating DHEA sulfate (DHEAS) and other sex hormone levels to those of younger adults using DHEA replacement therapy may be an effective strategy for increasing bone mineral density (BMD) in older adults. The available evidence to support this contention will be reviewed.
