ABSTRACT

Drug administration by intermittent IV infusion involves administration of short IV infusion repeatedly every xed dosing interval. Following repeated administration of these short IV infusions, the drug accumulates in the body until steady state is achieved. At steady state, the maximum and minimum plasma drug concentrations will be constant if the dose, infusion duration, and dosing interval are kept constant. This route of administration is usually used when bolus IV drug administration produces high plasma drug concentration that can produce serious adverse effects. Examples of drugs administered by this route of administration are vancomycin and aminoglycosides.