ABSTRACT
The number of approved protein and peptide drugs increased after the approval of recombinant human insulin in 1982. Since that time, the number of protein drugs approved has grown four to ve times, with sales reaching around $71 billion in 2008 (Trivedi et al., 2009b). However, development of these types of drugs has been hampered due to difculties in formulating and delivering them. This is because
5.1 Introduction .................................................................................................... 79 5.2 Deamidation Reaction ....................................................................................80
