ABSTRACT
Particle deposition is an important topic of concern to diverse areas of aerosol science and technology, ranging from the design and manufacture of equipment for aerosol generation and characterization to the study of human health effects in aerosol therapy and inhalation toxicology. This chapter shall focus on the application of aerosol science to particle deposition in the human respiratory system. Particle deposition in human airways is governed by multiple mechanisms. Inertial impaction, sedimentation, and diffusion are often considered the primary mechanisms of deposition, while interception, charging, and cloud motion may be important in some situations. These respective mechanisms are described and formulated in this chapter. The deposition ef†ciency of each mechanism is dependent upon interactions among aerosol characteristics, ventilatory parameters, and respiratory system morphologies.
