ABSTRACT

Maturation, functional activation, and migration of cells of the hematopoieticimmune system are based on interactions between the mobile immune cells and

2.1 Introduction .................................................................................................... 15 2.2 Relevance of Structural Correlations .............................................................. 16 2.3 Connexins and Gap Junctions in Bone Marrow ............................................. 17

2.3.1 Structural Evidence of Bone Marrow Gap Junctions ......................... 18 2.3.2 Gap Junctions in Normal, Regenerative, and Leukemic

Hematopoiesis ..................................................................................... 18 2.3.3 Hematopoietic Defects upon Connexin Gene Ablation ......................20