ABSTRACT
In drug development, cutaneous toxicity may be the result of direct or indirect causes and may occur after topical application or systemic administration. Mechanisms of cutaneous toxicity may involve chemical toxicity, immune-mediated causes, or photosensitization. The chemical structure (e.g., ultraviolet [UV] absorption) and characteristics (e.g., lipophilicity and antigenicity) of a compound, bioavailability (including metabolism and distribution to skin), skin location, and species can inuence the potential for dermatotoxicity and pattern of associated histopathologic changes observed.
