ABSTRACT
Physicians have traditionally determined the dosage of therapeutics for use in the paediatric population based on professional experience and the patient’s body weight. The problem with this approach is that children are not just small versions of adults. Major functional differences exist between human neonates, infants, children, and adults. Developing organs, organ systems, and metabolic pathways in children can react very differently to chemicals from those in fully developed adults (Beck et al. 2006).
