ABSTRACT
The marmoset monkey is an alternative non-human primate model in drug development (Abbott et al. 2003; Mansfield 2003; Orsi et al. 2011; Korte et al. 2004) and has also been used as a model for induced Parkinson’s and Huntington’s diseases, multiple sclerosis, and rheumatoid arthritis
8.4 Equipment .............................................................................................. 298 8.4.1 Surgical models ......................................................................... 298
8.4.1.1 Surgical facilities ........................................................ 298 8.4.1.2 Catheters/vascular access ports ............................... 299 8.4.1.3 External equipment ................................................... 300 8.4.1.4 Infusion pumps .......................................................... 300
8.4.2 Non-surgical models ................................................................ 301 8.4.2.1 Restraining devices .................................................... 301 8.4.2.2 Vascular access ........................................................... 301 8.4.2.3 Infusion pumps .......................................................... 301
8.5 Background data ................................................................................... 302 8.5.1 Surgical models ......................................................................... 302
8.5.1.1 Complications associated with the surgical process ......................................................................... 302
8.5.1.2 In-life changes ............................................................ 302 8.5.1.3 Pathology ..................................................................... 303
8.6 Conclusion ............................................................................................. 303 References ........................................................................................................ 305
(Vierboom et al. 2010). For biopharmaceutical drugs, nonhuman primates are the relevant animal model in 80% of the cases (Chapman et al. 2007, 2009, 2010). When it comes to justifying using marmosets instead of macaques, tissue cross-reactivity evaluation may eliminate these other nonhuman primate (NHP) species, with the marmoset monkey remaining the only relevant model.
