ABSTRACT

The rst step to the target compound 4 consisted of a regioselective silylation of the 6′-hydroxyl group of sucrose (1) using 1.1 equiv. of tert-butyldiphenylchlorosilane (TBDPSCl) in dry pyridine. The reaction was completed in 5 min under microwave irradiation (90°C, 300 W). The monosilylated sucrose 2 was benzylated using BnBr/ NaH reagent in DMF leading to compound 3 in 5 min (145°C, 300 W). Selective deprotection of the silyl group, using TBAF (tetrabutylammonium uoride), in THF led to 1′,2,3,3′,4,4′,6-hepta-O-benzyl-sucrose (4) in a good yield (75% or 32% overall from sucrose).