ABSTRACT
Introduction ................................................................................................................3 Human Genetic Variation ...........................................................................................4 Desirable Human Diet ................................................................................................6 Evidence for a Desirable Human Diet .......................................................................7 Desirable Human Diet and Human Genetic Variation ...............................................8 Nutrigenomics Toolkit ............................................................................................. 11
Transcriptomics ................................................................................................... 12 Proteomics ........................................................................................................... 12 Metabolomics ...................................................................................................... 12
Nutrigenomics and the Maintenance of Homeostasis .............................................. 13 Nutrigenomics and Preventive Health...................................................................... 14 Nutrigenomics and the Slowing of Disease Progression ......................................... 15 Functional Foods ...................................................................................................... 16
How to Produce a Functional Food ..................................................................... 16 Personalized Nutrition ............................................................................................. 19 Taking Personalized Nutrition to the Public ............................................................20 References ................................................................................................................ 21
and wellness. As new methods for judging these optimal levels are developed, the recommended daily amounts (RDAs) of many nutrients are changing, and are likely to continue to do so [1]. Most studies on nutrient requirements are limited by studying effects of nutrients one at a time. Nutrient-nutrient interactions and effects of the food matrix are also critical. Furthermore, much of the research to date has implied that all people have the same dietary requirements. It is increasingly clear that not all individuals will benet from an identical dietary regime, that is, they have a different nutritional phenotype. Although this may be partly a result of early dietary exposures and enzyme induction, as for example, with lactase deciency [2], or other factors such as stress or concomitant disease, it may also relate to individual genetic variations.
