ABSTRACT
This chapter describes the combination of optical coherence tomography (most commonly used to
visualize the microstructure of tissue) with light-induced fluorescence (which probes the biochemi-
cal composition of tissue). This combination has synergistic potential to accurately identify disease,
or to elucidate the basic structure and function of tissue. Because the two imaging modalities have
very different capabilities and technical requirements, combination into a dual-modality instrument
can be challenging, yet can be accomplished in many different configurations. This chapter will
examine the motivation for combined systems, several different instrumentation implementations,
and example successful applications.
