- Osmophobics and Hydrophobics: The Changing Landscape of Protein Folding

The underlying questions governing the transition of proteins from their unfolded state to their native state and recognition between proteins are as relevant now as they were 50 years ago (Annsen 1973). Misfolded (Weinreb et al. 1996) and unstructured domains (Dyson and Wright 2002, 2005) represent interesting examples of states where the understanding of recognition, and the self-recognition or folding process, has many biological implications (Weinreb et al. 1996; Wright and Dyson 1999; Uversky, Oldeld, and Dunker 2005; Chiti and Dobson 2006; Herczenik and Gebbink 2008).