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Basic Clinical Radiobiology
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Basic Clinical Radiobiology

Basic Clinical Radiobiology

ByMichael C. Joiner, Albert van der Kogel
Edition 4th Edition
First Published 2009
eBook Published 27 March 2009
Pub. location London
Imprint CRC Press
DOIhttps://doi.org/10.1201/b15450
Pages 375 pages
eBook ISBN 9781444109610
SubjectsMedicine, Dentistry, Nursing & Allied Health
Get Citation

Get Citation

Joiner, M., van der Kogel, A. (2009). Basic Clinical Radiobiology. London: CRC Press, https://doi.org/10.1201/b15450
ABOUT THIS BOOK

This concise but comprehensive textbook sets out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.

New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect. A variety of new authors have contributed to this revision, who, together with the new Editorial team, have used their significant international teaching experience to ensure the content remains clear and comprehensive, and as valuable to the trainee as it is to the established radiation oncologist.

With the fourth edition we will see the most radical change so far - as Professor Gordon Steel has retired as Editor and has been replaced by Bert van der Kogel, the current current course director for the above-mentioned course, plus Michael Joiner, who is the head of the Radiation Biology Program at the Wayne State University and is the Associate Editor of the International Journal of Radiation Biology.

TABLE OF CONTENTS
chapter 1|10 pages
Introduction: the significance of radiobiology and radiotherapy for cancer treatment MC Joiner, AJ van der Kogel and GG Steel
View abstract
chapter 2|16 pages
Irradiation-induced damage and the DNA damage response
ByBG Wouters and AC Begg
View abstract
chapter 3|14 pages
Cell death after irradiation: how, when and why cells die
ByBG Wouters
View abstract
chapter 4|15 pages
Quantifying cell kill and cell survival
ByMC Joiner
View abstract
chapter 5|12 pages
Dose–response relationships in radiotherapy
BySM Bentzen
View abstract
chapter 6|10 pages
Linear energy transfer and relative biological effectiveness
ByMC Joiner
View abstract
chapter 7|24 pages
Tumour growth and response to radiation
ByD Zips
View abstract
chapter 8|18 pages
Fractionation: the linear-quadratic approach
ByMC Joiner and SM Bentzen
View abstract
chapter 9|15 pages
The linear-quadratic approach in clinical practice
BySM Bentzen and MC Joiner
View abstract
chapter 10|14 pages
Modified fractionation
ByM Baumann, V Grégoire
View abstract
chapter 11|9 pages
Time factors in normal-tissue responses to irradiation
ByW Dörr
View abstract
chapter 12|11 pages
The dose-rate effect AJ van der Kogel
View abstract
chapter 13|22 pages
Pathogenesis of normal-tissue side-effects
ByW Dörr
View abstract
chapter 14|16 pages
The volume effect in radiotherapy
View abstract
chapter 15|17 pages
The oxygen effect and fractionated radiotherapy
ByMR Horsman, BG Wouters, MC Joiner and J Overgaard
View abstract
chapter 16|16 pages
The tumour microenvironment and cellular hypoxia responses
View abstract
chapter 17|13 pages
Therapeutic approaches to tumour hypoxia MR Horsman and AJ van der Kogel
View abstract
chapter 18|13 pages
Combined radiotherapy and chemotherapy
ByV Grégoire, M Baumann
View abstract
chapter 19|12 pages
Retreatment tolerance of normal tissues
ByW Dörr and FA Stewart
View abstract
chapter 20|16 pages
Molecular image-guided radiotherapy with positron emission tomography
ByV Grégoire, K Haustermans, J Lee
View abstract
chapter 21|14 pages
Molecular-targeted agents for enhancing tumour response
ByM Baumann, V Grégoire
View abstract
chapter 22|15 pages
Biological response modifiers: normal tissues
ByW Dörr
View abstract
chapter 23|16 pages
Molecular targeting and patient individualization
ByAC Begg
View abstract
chapter 24|7 pages
Protons and other ions in radiotherapy
ByW Dörr and MC Joiner
View abstract
chapter 25|14 pages
Second cancers after radiotherapy
ByKR Trott
View abstract

This concise but comprehensive textbook sets out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.

New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect. A variety of new authors have contributed to this revision, who, together with the new Editorial team, have used their significant international teaching experience to ensure the content remains clear and comprehensive, and as valuable to the trainee as it is to the established radiation oncologist.

With the fourth edition we will see the most radical change so far - as Professor Gordon Steel has retired as Editor and has been replaced by Bert van der Kogel, the current current course director for the above-mentioned course, plus Michael Joiner, who is the head of the Radiation Biology Program at the Wayne State University and is the Associate Editor of the International Journal of Radiation Biology.

TABLE OF CONTENTS
chapter 1|10 pages
Introduction: the significance of radiobiology and radiotherapy for cancer treatment MC Joiner, AJ van der Kogel and GG Steel
View abstract
chapter 2|16 pages
Irradiation-induced damage and the DNA damage response
ByBG Wouters and AC Begg
View abstract
chapter 3|14 pages
Cell death after irradiation: how, when and why cells die
ByBG Wouters
View abstract
chapter 4|15 pages
Quantifying cell kill and cell survival
ByMC Joiner
View abstract
chapter 5|12 pages
Dose–response relationships in radiotherapy
BySM Bentzen
View abstract
chapter 6|10 pages
Linear energy transfer and relative biological effectiveness
ByMC Joiner
View abstract
chapter 7|24 pages
Tumour growth and response to radiation
ByD Zips
View abstract
chapter 8|18 pages
Fractionation: the linear-quadratic approach
ByMC Joiner and SM Bentzen
View abstract
chapter 9|15 pages
The linear-quadratic approach in clinical practice
BySM Bentzen and MC Joiner
View abstract
chapter 10|14 pages
Modified fractionation
ByM Baumann, V Grégoire
View abstract
chapter 11|9 pages
Time factors in normal-tissue responses to irradiation
ByW Dörr
View abstract
chapter 12|11 pages
The dose-rate effect AJ van der Kogel
View abstract
chapter 13|22 pages
Pathogenesis of normal-tissue side-effects
ByW Dörr
View abstract
chapter 14|16 pages
The volume effect in radiotherapy
View abstract
chapter 15|17 pages
The oxygen effect and fractionated radiotherapy
ByMR Horsman, BG Wouters, MC Joiner and J Overgaard
View abstract
chapter 16|16 pages
The tumour microenvironment and cellular hypoxia responses
View abstract
chapter 17|13 pages
Therapeutic approaches to tumour hypoxia MR Horsman and AJ van der Kogel
View abstract
chapter 18|13 pages
Combined radiotherapy and chemotherapy
ByV Grégoire, M Baumann
View abstract
chapter 19|12 pages
Retreatment tolerance of normal tissues
ByW Dörr and FA Stewart
View abstract
chapter 20|16 pages
Molecular image-guided radiotherapy with positron emission tomography
ByV Grégoire, K Haustermans, J Lee
View abstract
chapter 21|14 pages
Molecular-targeted agents for enhancing tumour response
ByM Baumann, V Grégoire
View abstract
chapter 22|15 pages
Biological response modifiers: normal tissues
ByW Dörr
View abstract
chapter 23|16 pages
Molecular targeting and patient individualization
ByAC Begg
View abstract
chapter 24|7 pages
Protons and other ions in radiotherapy
ByW Dörr and MC Joiner
View abstract
chapter 25|14 pages
Second cancers after radiotherapy
ByKR Trott
View abstract
CONTENTS
ABOUT THIS BOOK

This concise but comprehensive textbook sets out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.

New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect. A variety of new authors have contributed to this revision, who, together with the new Editorial team, have used their significant international teaching experience to ensure the content remains clear and comprehensive, and as valuable to the trainee as it is to the established radiation oncologist.

With the fourth edition we will see the most radical change so far - as Professor Gordon Steel has retired as Editor and has been replaced by Bert van der Kogel, the current current course director for the above-mentioned course, plus Michael Joiner, who is the head of the Radiation Biology Program at the Wayne State University and is the Associate Editor of the International Journal of Radiation Biology.

TABLE OF CONTENTS
chapter 1|10 pages
Introduction: the significance of radiobiology and radiotherapy for cancer treatment MC Joiner, AJ van der Kogel and GG Steel
View abstract
chapter 2|16 pages
Irradiation-induced damage and the DNA damage response
ByBG Wouters and AC Begg
View abstract
chapter 3|14 pages
Cell death after irradiation: how, when and why cells die
ByBG Wouters
View abstract
chapter 4|15 pages
Quantifying cell kill and cell survival
ByMC Joiner
View abstract
chapter 5|12 pages
Dose–response relationships in radiotherapy
BySM Bentzen
View abstract
chapter 6|10 pages
Linear energy transfer and relative biological effectiveness
ByMC Joiner
View abstract
chapter 7|24 pages
Tumour growth and response to radiation
ByD Zips
View abstract
chapter 8|18 pages
Fractionation: the linear-quadratic approach
ByMC Joiner and SM Bentzen
View abstract
chapter 9|15 pages
The linear-quadratic approach in clinical practice
BySM Bentzen and MC Joiner
View abstract
chapter 10|14 pages
Modified fractionation
ByM Baumann, V Grégoire
View abstract
chapter 11|9 pages
Time factors in normal-tissue responses to irradiation
ByW Dörr
View abstract
chapter 12|11 pages
The dose-rate effect AJ van der Kogel
View abstract
chapter 13|22 pages
Pathogenesis of normal-tissue side-effects
ByW Dörr
View abstract
chapter 14|16 pages
The volume effect in radiotherapy
View abstract
chapter 15|17 pages
The oxygen effect and fractionated radiotherapy
ByMR Horsman, BG Wouters, MC Joiner and J Overgaard
View abstract
chapter 16|16 pages
The tumour microenvironment and cellular hypoxia responses
View abstract
chapter 17|13 pages
Therapeutic approaches to tumour hypoxia MR Horsman and AJ van der Kogel
View abstract
chapter 18|13 pages
Combined radiotherapy and chemotherapy
ByV Grégoire, M Baumann
View abstract
chapter 19|12 pages
Retreatment tolerance of normal tissues
ByW Dörr and FA Stewart
View abstract
chapter 20|16 pages
Molecular image-guided radiotherapy with positron emission tomography
ByV Grégoire, K Haustermans, J Lee
View abstract
chapter 21|14 pages
Molecular-targeted agents for enhancing tumour response
ByM Baumann, V Grégoire
View abstract
chapter 22|15 pages
Biological response modifiers: normal tissues
ByW Dörr
View abstract
chapter 23|16 pages
Molecular targeting and patient individualization
ByAC Begg
View abstract
chapter 24|7 pages
Protons and other ions in radiotherapy
ByW Dörr and MC Joiner
View abstract
chapter 25|14 pages
Second cancers after radiotherapy
ByKR Trott
View abstract

This concise but comprehensive textbook sets out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.

New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect. A variety of new authors have contributed to this revision, who, together with the new Editorial team, have used their significant international teaching experience to ensure the content remains clear and comprehensive, and as valuable to the trainee as it is to the established radiation oncologist.

With the fourth edition we will see the most radical change so far - as Professor Gordon Steel has retired as Editor and has been replaced by Bert van der Kogel, the current current course director for the above-mentioned course, plus Michael Joiner, who is the head of the Radiation Biology Program at the Wayne State University and is the Associate Editor of the International Journal of Radiation Biology.

TABLE OF CONTENTS
chapter 1|10 pages
Introduction: the significance of radiobiology and radiotherapy for cancer treatment MC Joiner, AJ van der Kogel and GG Steel
View abstract
chapter 2|16 pages
Irradiation-induced damage and the DNA damage response
ByBG Wouters and AC Begg
View abstract
chapter 3|14 pages
Cell death after irradiation: how, when and why cells die
ByBG Wouters
View abstract
chapter 4|15 pages
Quantifying cell kill and cell survival
ByMC Joiner
View abstract
chapter 5|12 pages
Dose–response relationships in radiotherapy
BySM Bentzen
View abstract
chapter 6|10 pages
Linear energy transfer and relative biological effectiveness
ByMC Joiner
View abstract
chapter 7|24 pages
Tumour growth and response to radiation
ByD Zips
View abstract
chapter 8|18 pages
Fractionation: the linear-quadratic approach
ByMC Joiner and SM Bentzen
View abstract
chapter 9|15 pages
The linear-quadratic approach in clinical practice
BySM Bentzen and MC Joiner
View abstract
chapter 10|14 pages
Modified fractionation
ByM Baumann, V Grégoire
View abstract
chapter 11|9 pages
Time factors in normal-tissue responses to irradiation
ByW Dörr
View abstract
chapter 12|11 pages
The dose-rate effect AJ van der Kogel
View abstract
chapter 13|22 pages
Pathogenesis of normal-tissue side-effects
ByW Dörr
View abstract
chapter 14|16 pages
The volume effect in radiotherapy
View abstract
chapter 15|17 pages
The oxygen effect and fractionated radiotherapy
ByMR Horsman, BG Wouters, MC Joiner and J Overgaard
View abstract
chapter 16|16 pages
The tumour microenvironment and cellular hypoxia responses
View abstract
chapter 17|13 pages
Therapeutic approaches to tumour hypoxia MR Horsman and AJ van der Kogel
View abstract
chapter 18|13 pages
Combined radiotherapy and chemotherapy
ByV Grégoire, M Baumann
View abstract
chapter 19|12 pages
Retreatment tolerance of normal tissues
ByW Dörr and FA Stewart
View abstract
chapter 20|16 pages
Molecular image-guided radiotherapy with positron emission tomography
ByV Grégoire, K Haustermans, J Lee
View abstract
chapter 21|14 pages
Molecular-targeted agents for enhancing tumour response
ByM Baumann, V Grégoire
View abstract
chapter 22|15 pages
Biological response modifiers: normal tissues
ByW Dörr
View abstract
chapter 23|16 pages
Molecular targeting and patient individualization
ByAC Begg
View abstract
chapter 24|7 pages
Protons and other ions in radiotherapy
ByW Dörr and MC Joiner
View abstract
chapter 25|14 pages
Second cancers after radiotherapy
ByKR Trott
View abstract
ABOUT THIS BOOK
ABOUT THIS BOOK

This concise but comprehensive textbook sets out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.

New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect. A variety of new authors have contributed to this revision, who, together with the new Editorial team, have used their significant international teaching experience to ensure the content remains clear and comprehensive, and as valuable to the trainee as it is to the established radiation oncologist.

With the fourth edition we will see the most radical change so far - as Professor Gordon Steel has retired as Editor and has been replaced by Bert van der Kogel, the current current course director for the above-mentioned course, plus Michael Joiner, who is the head of the Radiation Biology Program at the Wayne State University and is the Associate Editor of the International Journal of Radiation Biology.

TABLE OF CONTENTS
chapter 1|10 pages
Introduction: the significance of radiobiology and radiotherapy for cancer treatment MC Joiner, AJ van der Kogel and GG Steel
View abstract
chapter 2|16 pages
Irradiation-induced damage and the DNA damage response
ByBG Wouters and AC Begg
View abstract
chapter 3|14 pages
Cell death after irradiation: how, when and why cells die
ByBG Wouters
View abstract
chapter 4|15 pages
Quantifying cell kill and cell survival
ByMC Joiner
View abstract
chapter 5|12 pages
Dose–response relationships in radiotherapy
BySM Bentzen
View abstract
chapter 6|10 pages
Linear energy transfer and relative biological effectiveness
ByMC Joiner
View abstract
chapter 7|24 pages
Tumour growth and response to radiation
ByD Zips
View abstract
chapter 8|18 pages
Fractionation: the linear-quadratic approach
ByMC Joiner and SM Bentzen
View abstract
chapter 9|15 pages
The linear-quadratic approach in clinical practice
BySM Bentzen and MC Joiner
View abstract
chapter 10|14 pages
Modified fractionation
ByM Baumann, V Grégoire
View abstract
chapter 11|9 pages
Time factors in normal-tissue responses to irradiation
ByW Dörr
View abstract
chapter 12|11 pages
The dose-rate effect AJ van der Kogel
View abstract
chapter 13|22 pages
Pathogenesis of normal-tissue side-effects
ByW Dörr
View abstract
chapter 14|16 pages
The volume effect in radiotherapy
View abstract
chapter 15|17 pages
The oxygen effect and fractionated radiotherapy
ByMR Horsman, BG Wouters, MC Joiner and J Overgaard
View abstract
chapter 16|16 pages
The tumour microenvironment and cellular hypoxia responses
View abstract
chapter 17|13 pages
Therapeutic approaches to tumour hypoxia MR Horsman and AJ van der Kogel
View abstract
chapter 18|13 pages
Combined radiotherapy and chemotherapy
ByV Grégoire, M Baumann
View abstract
chapter 19|12 pages
Retreatment tolerance of normal tissues
ByW Dörr and FA Stewart
View abstract
chapter 20|16 pages
Molecular image-guided radiotherapy with positron emission tomography
ByV Grégoire, K Haustermans, J Lee
View abstract
chapter 21|14 pages
Molecular-targeted agents for enhancing tumour response
ByM Baumann, V Grégoire
View abstract
chapter 22|15 pages
Biological response modifiers: normal tissues
ByW Dörr
View abstract
chapter 23|16 pages
Molecular targeting and patient individualization
ByAC Begg
View abstract
chapter 24|7 pages
Protons and other ions in radiotherapy
ByW Dörr and MC Joiner
View abstract
chapter 25|14 pages
Second cancers after radiotherapy
ByKR Trott
View abstract

This concise but comprehensive textbook sets out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.

New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect. A variety of new authors have contributed to this revision, who, together with the new Editorial team, have used their significant international teaching experience to ensure the content remains clear and comprehensive, and as valuable to the trainee as it is to the established radiation oncologist.

With the fourth edition we will see the most radical change so far - as Professor Gordon Steel has retired as Editor and has been replaced by Bert van der Kogel, the current current course director for the above-mentioned course, plus Michael Joiner, who is the head of the Radiation Biology Program at the Wayne State University and is the Associate Editor of the International Journal of Radiation Biology.

TABLE OF CONTENTS
chapter 1|10 pages
Introduction: the significance of radiobiology and radiotherapy for cancer treatment MC Joiner, AJ van der Kogel and GG Steel
View abstract
chapter 2|16 pages
Irradiation-induced damage and the DNA damage response
ByBG Wouters and AC Begg
View abstract
chapter 3|14 pages
Cell death after irradiation: how, when and why cells die
ByBG Wouters
View abstract
chapter 4|15 pages
Quantifying cell kill and cell survival
ByMC Joiner
View abstract
chapter 5|12 pages
Dose–response relationships in radiotherapy
BySM Bentzen
View abstract
chapter 6|10 pages
Linear energy transfer and relative biological effectiveness
ByMC Joiner
View abstract
chapter 7|24 pages
Tumour growth and response to radiation
ByD Zips
View abstract
chapter 8|18 pages
Fractionation: the linear-quadratic approach
ByMC Joiner and SM Bentzen
View abstract
chapter 9|15 pages
The linear-quadratic approach in clinical practice
BySM Bentzen and MC Joiner
View abstract
chapter 10|14 pages
Modified fractionation
ByM Baumann, V Grégoire
View abstract
chapter 11|9 pages
Time factors in normal-tissue responses to irradiation
ByW Dörr
View abstract
chapter 12|11 pages
The dose-rate effect AJ van der Kogel
View abstract
chapter 13|22 pages
Pathogenesis of normal-tissue side-effects
ByW Dörr
View abstract
chapter 14|16 pages
The volume effect in radiotherapy
View abstract
chapter 15|17 pages
The oxygen effect and fractionated radiotherapy
ByMR Horsman, BG Wouters, MC Joiner and J Overgaard
View abstract
chapter 16|16 pages
The tumour microenvironment and cellular hypoxia responses
View abstract
chapter 17|13 pages
Therapeutic approaches to tumour hypoxia MR Horsman and AJ van der Kogel
View abstract
chapter 18|13 pages
Combined radiotherapy and chemotherapy
ByV Grégoire, M Baumann
View abstract
chapter 19|12 pages
Retreatment tolerance of normal tissues
ByW Dörr and FA Stewart
View abstract
chapter 20|16 pages
Molecular image-guided radiotherapy with positron emission tomography
ByV Grégoire, K Haustermans, J Lee
View abstract
chapter 21|14 pages
Molecular-targeted agents for enhancing tumour response
ByM Baumann, V Grégoire
View abstract
chapter 22|15 pages
Biological response modifiers: normal tissues
ByW Dörr
View abstract
chapter 23|16 pages
Molecular targeting and patient individualization
ByAC Begg
View abstract
chapter 24|7 pages
Protons and other ions in radiotherapy
ByW Dörr and MC Joiner
View abstract
chapter 25|14 pages
Second cancers after radiotherapy
ByKR Trott
View abstract
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