ABSTRACT
In the vast majority of cases no aetiological factors can be identified. Several associations have been identified but these conditions are them-
selves very rare. Genetic predisposition to CNS tumours has been identified in the following rare syndromes:
■ neurofibromatosis – neurofibroma, and neurofibrosarcoma, optic nerve glioma, ependymoma, meningioma
■ tuberose sclerosis – glioma and hamartoma ■ Von Hippel-Lindau syndrome – cerebellar
haemangioblastoma ■ Li-Fraumeni syndrome – gliomas ■ Gorlin’s syndrome – medulloblastoma.