ABSTRACT
Phosphorylation is a fundamental biological process conserved in prokaryotes and eukaryotes and controls the function of a wide variety of cellular proteins (1). Ion channels are no exception, and studies over the past few decades have provided striking examples of the fundamental role of phosphorylation as determinants of ion channel expression, localization and function, and in important physiological events mediated by dynamic and reversible changes in this phosphorylation. In this chapter, we will cover known phosphorylation on voltage-gated ion channel proteins and how they aect diverse aspects of the function of these proteins, as well as recent advances in the methodology to study ion channel phosphorylation.
