ABSTRACT

Silica, because of its abundance in Earth’s crust, presents numerous opportunities for human exposure. Between the two forms (amorphous and crystalline) of silica† present, crystalline silica assumes a major importance with respect to potential harmful human health effects. Even though

18.1 Introduction .......................................................................................................................... 423 18.1.1 Exposure to Crystalline Silica .................................................................................. 423 18.1.2 Health Effects of Crystalline Silica Exposure ..........................................................424 18.1.3 Transcriptome: A Sensitive and Mechanistically Relevant Target for Toxicity .......424

18.2 Transcriptomic Responses to Crystalline Silica Exposure ................................................... 425 18.2.1 Transcriptomic Response to Crystalline Silica Exposure Corresponds