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Absolute Risk
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Absolute Risk

Methods and Applications in Clinical Management and Public Health

Absolute Risk

Methods and Applications in Clinical Management and Public Health

ByRuth M. Pfeiffer, Mitchell H. Gail
Edition 1st Edition
First Published 2017
eBook Published 10 August 2017
Pub. location New York
Imprint Chapman and Hall/CRC
DOIhttps://doi.org/10.1201/9781315117539
Pages 225 pages
eBook ISBN 9781466561687
SubjectsBioscience, Earth Sciences, Mathematics & Statistics
KeywordsAbsolute Risk, Breast Cancer Risk Assessment Tool, Breast Cancer, Breast Cancer Risk, Absolute Risk Estimates
Get Citation

Get Citation

Pfeiffer, R., Gail, M. (2018). Absolute Risk. New York: Chapman and Hall/CRC, https://doi.org/10.1201/9781315117539
ABOUT THIS BOOK

Absolute Risk: Methods and Applications in Clinical Management and Public Health provides theory and examples to demonstrate the importance of absolute risk in counseling patients, devising public health strategies, and clinical management. The book provides sufficient technical detail to allow statisticians, epidemiologists, and clinicians to build, test, and apply models of absolute risk.

Features:

  • Provides theoretical basis for modeling absolute risk, including competing risks and cause-specific and cumulative incidence regression
  • Discusses various sampling designs for estimating absolute risk and criteria to evaluate models
  • Provides details on statistical inference for the various sampling designs
  • Discusses criteria for evaluating risk models and comparing risk models, including both general criteria and problem-specific expected losses in well-defined clinical and public health applications
  • Describes many applications encompassing both disease prevention and prognosis, and ranging from counseling individual patients, to clinical decision making, to assessing the impact of risk-based public health strategies
  • Discusses model updating, family-based designs, dynamic projections, and other topics

Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis.

Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association.

Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.

TABLE OF CONTENTS
chapter 1|9 pages
Introduction
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 2|8 pages
Definitions and basic concepts for survival data in a cohort without covariates
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 3|7 pages
Competing risks
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 4|35 pages
Regression models for absolute risk estimated from cohort data
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 5|11 pages
Estimating absolute risk by combining case-control or cohort data with disease registry data
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 6|26 pages
Assessment of risk model performance
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 7|17 pages
Comparing the performance of two models
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 8|16 pages
Building and updating relative risk models
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 9|15 pages
Risk estimates based on genetic variants and family studies
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 10|20 pages
Related topics
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract

Absolute Risk: Methods and Applications in Clinical Management and Public Health provides theory and examples to demonstrate the importance of absolute risk in counseling patients, devising public health strategies, and clinical management. The book provides sufficient technical detail to allow statisticians, epidemiologists, and clinicians to build, test, and apply models of absolute risk.

Features:

  • Provides theoretical basis for modeling absolute risk, including competing risks and cause-specific and cumulative incidence regression
  • Discusses various sampling designs for estimating absolute risk and criteria to evaluate models
  • Provides details on statistical inference for the various sampling designs
  • Discusses criteria for evaluating risk models and comparing risk models, including both general criteria and problem-specific expected losses in well-defined clinical and public health applications
  • Describes many applications encompassing both disease prevention and prognosis, and ranging from counseling individual patients, to clinical decision making, to assessing the impact of risk-based public health strategies
  • Discusses model updating, family-based designs, dynamic projections, and other topics

Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis.

Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association.

Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.

TABLE OF CONTENTS
chapter 1|9 pages
Introduction
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 2|8 pages
Definitions and basic concepts for survival data in a cohort without covariates
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 3|7 pages
Competing risks
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 4|35 pages
Regression models for absolute risk estimated from cohort data
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 5|11 pages
Estimating absolute risk by combining case-control or cohort data with disease registry data
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 6|26 pages
Assessment of risk model performance
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 7|17 pages
Comparing the performance of two models
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 8|16 pages
Building and updating relative risk models
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 9|15 pages
Risk estimates based on genetic variants and family studies
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 10|20 pages
Related topics
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
CONTENTS
ABOUT THIS BOOK

Absolute Risk: Methods and Applications in Clinical Management and Public Health provides theory and examples to demonstrate the importance of absolute risk in counseling patients, devising public health strategies, and clinical management. The book provides sufficient technical detail to allow statisticians, epidemiologists, and clinicians to build, test, and apply models of absolute risk.

Features:

  • Provides theoretical basis for modeling absolute risk, including competing risks and cause-specific and cumulative incidence regression
  • Discusses various sampling designs for estimating absolute risk and criteria to evaluate models
  • Provides details on statistical inference for the various sampling designs
  • Discusses criteria for evaluating risk models and comparing risk models, including both general criteria and problem-specific expected losses in well-defined clinical and public health applications
  • Describes many applications encompassing both disease prevention and prognosis, and ranging from counseling individual patients, to clinical decision making, to assessing the impact of risk-based public health strategies
  • Discusses model updating, family-based designs, dynamic projections, and other topics

Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis.

Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association.

Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.

TABLE OF CONTENTS
chapter 1|9 pages
Introduction
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 2|8 pages
Definitions and basic concepts for survival data in a cohort without covariates
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 3|7 pages
Competing risks
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 4|35 pages
Regression models for absolute risk estimated from cohort data
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 5|11 pages
Estimating absolute risk by combining case-control or cohort data with disease registry data
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 6|26 pages
Assessment of risk model performance
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 7|17 pages
Comparing the performance of two models
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 8|16 pages
Building and updating relative risk models
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 9|15 pages
Risk estimates based on genetic variants and family studies
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 10|20 pages
Related topics
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract

Absolute Risk: Methods and Applications in Clinical Management and Public Health provides theory and examples to demonstrate the importance of absolute risk in counseling patients, devising public health strategies, and clinical management. The book provides sufficient technical detail to allow statisticians, epidemiologists, and clinicians to build, test, and apply models of absolute risk.

Features:

  • Provides theoretical basis for modeling absolute risk, including competing risks and cause-specific and cumulative incidence regression
  • Discusses various sampling designs for estimating absolute risk and criteria to evaluate models
  • Provides details on statistical inference for the various sampling designs
  • Discusses criteria for evaluating risk models and comparing risk models, including both general criteria and problem-specific expected losses in well-defined clinical and public health applications
  • Describes many applications encompassing both disease prevention and prognosis, and ranging from counseling individual patients, to clinical decision making, to assessing the impact of risk-based public health strategies
  • Discusses model updating, family-based designs, dynamic projections, and other topics

Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis.

Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association.

Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.

TABLE OF CONTENTS
chapter 1|9 pages
Introduction
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 2|8 pages
Definitions and basic concepts for survival data in a cohort without covariates
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 3|7 pages
Competing risks
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 4|35 pages
Regression models for absolute risk estimated from cohort data
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 5|11 pages
Estimating absolute risk by combining case-control or cohort data with disease registry data
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 6|26 pages
Assessment of risk model performance
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 7|17 pages
Comparing the performance of two models
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 8|16 pages
Building and updating relative risk models
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 9|15 pages
Risk estimates based on genetic variants and family studies
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 10|20 pages
Related topics
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
ABOUT THIS BOOK
ABOUT THIS BOOK

Absolute Risk: Methods and Applications in Clinical Management and Public Health provides theory and examples to demonstrate the importance of absolute risk in counseling patients, devising public health strategies, and clinical management. The book provides sufficient technical detail to allow statisticians, epidemiologists, and clinicians to build, test, and apply models of absolute risk.

Features:

  • Provides theoretical basis for modeling absolute risk, including competing risks and cause-specific and cumulative incidence regression
  • Discusses various sampling designs for estimating absolute risk and criteria to evaluate models
  • Provides details on statistical inference for the various sampling designs
  • Discusses criteria for evaluating risk models and comparing risk models, including both general criteria and problem-specific expected losses in well-defined clinical and public health applications
  • Describes many applications encompassing both disease prevention and prognosis, and ranging from counseling individual patients, to clinical decision making, to assessing the impact of risk-based public health strategies
  • Discusses model updating, family-based designs, dynamic projections, and other topics

Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis.

Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association.

Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.

TABLE OF CONTENTS
chapter 1|9 pages
Introduction
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 2|8 pages
Definitions and basic concepts for survival data in a cohort without covariates
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 3|7 pages
Competing risks
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 4|35 pages
Regression models for absolute risk estimated from cohort data
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 5|11 pages
Estimating absolute risk by combining case-control or cohort data with disease registry data
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 6|26 pages
Assessment of risk model performance
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 7|17 pages
Comparing the performance of two models
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 8|16 pages
Building and updating relative risk models
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 9|15 pages
Risk estimates based on genetic variants and family studies
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 10|20 pages
Related topics
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract

Absolute Risk: Methods and Applications in Clinical Management and Public Health provides theory and examples to demonstrate the importance of absolute risk in counseling patients, devising public health strategies, and clinical management. The book provides sufficient technical detail to allow statisticians, epidemiologists, and clinicians to build, test, and apply models of absolute risk.

Features:

  • Provides theoretical basis for modeling absolute risk, including competing risks and cause-specific and cumulative incidence regression
  • Discusses various sampling designs for estimating absolute risk and criteria to evaluate models
  • Provides details on statistical inference for the various sampling designs
  • Discusses criteria for evaluating risk models and comparing risk models, including both general criteria and problem-specific expected losses in well-defined clinical and public health applications
  • Describes many applications encompassing both disease prevention and prognosis, and ranging from counseling individual patients, to clinical decision making, to assessing the impact of risk-based public health strategies
  • Discusses model updating, family-based designs, dynamic projections, and other topics

Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis.

Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association.

Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.

TABLE OF CONTENTS
chapter 1|9 pages
Introduction
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 2|8 pages
Definitions and basic concepts for survival data in a cohort without covariates
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 3|7 pages
Competing risks
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 4|35 pages
Regression models for absolute risk estimated from cohort data
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 5|11 pages
Estimating absolute risk by combining case-control or cohort data with disease registry data
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 6|26 pages
Assessment of risk model performance
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 7|17 pages
Comparing the performance of two models
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 8|16 pages
Building and updating relative risk models
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 9|15 pages
Risk estimates based on genetic variants and family studies
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
chapter 10|20 pages
Related topics
ByRuth M. Pfeiffer, Mitchell H. Gail
View abstract
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