ABSTRACT

Quantification by GC-MS coupling obeys precise rules. The development of a dosage method by GC-MS can seem long and tedious to novice users, but device programming for quantification does not represent a problem. The preparation of samples generally takes more time and also requires precision and rigor. The validation of the dosage method requires many analyses over several days and can be a source of discouragement, but dosage results can be considered reliable only if the quantification method has been validated first.