ABSTRACT
Metabolomics (or metabonomics) is the study of the diverse metabolic profi le of a given cell, tissue, fl uid, organ, or organism, and its intermediates that refl ect biological status with change of metabolome, the collection of all metabolites produced in biological systems. Studies using metabolomics, a newly categorized ‘-omics’, can provide insight into generation of pattern recognition-based models for classifi cation or prediction of changes in biological metabolism (1-3). Relatively small-molecular metabolites (M.W. 100-1000) have an important role in biological systems and in understanding of disease status (1) defi ned metabonomics as the quantitative measurement of the dynamic multi-parametric metabolic response of living systems to patho-physiological stimuli or genetic modifi cation. In the fi eld of metabolomics, the strategy is to detect changes in the distribution and concentration of a broad range of endogenous metabolites; this strategy can be applied to multiple levels of biological systems (4).
