ABSTRACT
Huntington’s disease (HD) is an autosomal dominant disorder caused by an expanded and unstable CAG trinucleotide repeat that causes a progressive degeneration of neurons, primarily in the putamen, caudate nucleus, and cerebral cortex (The Huntington’s Disease Collaborative Research Group, 1993). In the United States, there is estimated to be approximately 30,000
1 Program in Neuroscience, Central Michigan University, Mt. Pleasant MI, USA. 2College of Medicine, Central Michigan University, Mt. Pleasant MI, USA. 3Field Neurosciences Institute, Saginaw MI, USA. 4INSERM UMR 643/1064, Université de Nantes, Nantes, France. 5Faculté de Médecine, Université de Nantes, Nantes, France. 6Faculté des Science et des Techniques, Université de Nantes, Nantes, France. 7 INSERM UMR 791, LIOAD, Université de Nantes, Nantes, France. 8UFR d’Odontologie, Université de Nantes, Nantes, France. 9Centre Hospitalier-Universitaire (CHU) de Nantes, Nantes, France. *Corresponding author: dunba1g@cmich.edu
individuals with HD. Europe has a slightly higher prevalence of individuals with symptomatic HD, with an estimated 45,000 patients (Shoulson and Young, 2011).
