ABSTRACT
Nanoparticles are colloidal systems that vary in size from 10 to 1,000 nm. According to the bibliography, they have been used in biology and medicine for over 50 years. Many research laboratories around the world are now focusing on the development of diagnostic and therapeutic agents based upon radiolabeled peptides, proteins, affibodies or scaffold proteins, including nanoparticles. Radiolabeled nanoparticles designed for specific transport of therapeutic agents to diseased tissues have received attention over the last decades, because they have potential as radiotracers in the visualization of tumors and metastases. Radionuclides are bound to nanoparticles and inoculated into the human tissues, where they decay emitting particles (a, b+, b-,Auger electrons). Nanoparticles used as nanocarriers are characterized by their long circulation half-life and high accumulation in tumors due to their rapid penetration in human tissues.
