ABSTRACT
Quantal response bioassays with multiple explanatory variables are far more efficient in demonstrating the effects of variables other than dose on response. Single variable experiments waste time, test subjects, and financial resources. Just in case diet is a significant factor, Jessica will record binary responses (dead or alive), doses, and diet for each larva. This type of bioassay is a binary quantal response experiment with multiple explanatory variables. The primary reason for use of binary response bioassays with multiple explanatory variables is simple: Compared with a single experiment in which significance of several variables is tested simultaneously, multiple experiments with single variables are inefficient. The presence of more than one explanatory variable makes the statistical methods used to estimate the probability of response and values of the coefficients far more complex than those previously described for binary quantal response with only one explanatory variable.
