ABSTRACT

Nasal drug delivery is ideally suited to the topical treatment of local nasal conditions, such as the common cold, allergic and nonallergic rhinitis, nasal polyps, and chronic nasal and sinus inammations. Drugs for topical delivery include antihistamines (e.g., azelastine), anti-inammatory corticosteroids (e.g., budesonide and uticasone), and topical nasal decongestants (e.g., oxymetazoline and xylometazoline). The idea is that delivered locally, these drugs are effectively targeted to their site of action, which should maximize their therapeutic effect while minimizing unwanted side effects.