ABSTRACT
A discrete event simulation (DES) is a mathematical framework for addressing a problem-for health technology assessment (HTA), this has to do with the health and economic implications of employing a new intervention in the health care system. At the core of this mathematical framework is a set of equations that expresses numerically the relationships among the various factors. Although the number and type of equations in a DES vary based on the nature and complexity of the disease or outcomes modeled, the approach to building those equations is the same (Table 6.1). First, you must find appropriate sources of data. Often this is the most arduous part of the process. Then, you must determine which distribution will be applied to these data and what predictors should be included. Finally, the resulting equations have to be validated.
