ABSTRACT
Indole-3-carbinol and 3,3′-diindolylmethane are present in plants and medicinal herbs. These compounds exerted anticancer effects on prostate cancer cells through the inhibition of androgen-and estrogen-mediated pathways [1], and also showed inductive effects on xenobiotic metabolism. Both compounds are cyclin inhibitors and induced cell cycle arrest through the inhibition of insulin-like growth factor receptor 1 expression. However, both compounds showed different modes of action and efcacies due probably to a differential effect on binding afnity with mechanisms both dependent and independent of androgen receptor and aryl hydrocarbon receptor. Broccoli-derived phytochemicals also show pleiotrophic effects on cell growth and signaling pathways associated with cell proliferation. The results suggest that indole-3-carbinol and 3,3′-diindolylmethane can be developed as chemoprotective agents for cancer therapy.
