ABSTRACT

Positron Emission Tomography (PET) is one of the older neuroimaging techniques, having been first realised in the early 1950s with roots even further back (42) and with significant development in the early 1980s. PET is a non-invasive imaging technique, but works on the principle of using injected radiotracers (radioactive compounds present in tracer amounts) with specific biochemical properties to mimic systems in the body or actions of other known non-radio-labelled chemical compounds. The emission of positrons is observed using a PET tomograph scanner, which can produce three-dimensional images over time of the concentrations of the radio-labelled compounds.