ABSTRACT
As discussed in Chapter 9, the PK/TK models describe in a quantitative manner some salient features of mammalian systems in handling xenobiotics. The focus of this chapter is to evaluate the properties of these models following the instantaneous input into the systemic circulation. The purpose is to describe the complex biological processes involved in handling the xenobiotics more explicitly in terms of model dependent parameters and constant. The instantaneous input (intravenous bolus injection) enables one to evaluate the disposition (distribution, metabolism, and excretion) of a compound without the complications associated with the passage across the boundary between the body and environment or complex barrier of the GI tract. This establishes the intravenous (IV) bolus data as reference for bioavailability evaluations and similar considerations.
