ABSTRACT
This chapter presents classification & mode of action, indications & dermatological uses, formulations/presentation, dosages & suggested regimens, baseline investigations, considerations & monitoring, contraindications, cautions, important drug interactions, adverse effects & their management, use in special situations, and essential patient information of Ciclosporin. Ciclosporin is a lipophilic cyclic undecapeptide with a molecular weight of 1202 daltons. Ciclosporin exerts immunomodulatory effects mainly by preventing the activation of T-lymphocytes which are implicated in the pathogenesis of inflammatory skin disorders such as psoriasis and atopic dermatitis. Ciclosporin is metabolized by the cytochrome P450 enzyme system in the liver and therefore has many potential drug interactions. Ciclosporin has been used for the treatment of inflammatory bowel disease, nephrotic syndrome and rheumatoid arthritis. Ciclosporin has been shown to greatly improve the quality of life in patients with psoriasis in randomized controlled trials. Differences may occur in the bioavailability of the various formulations and brands of ciclosporin.
