ABSTRACT
This chapter presents classification & mode of action, indications & dermatological uses, formulations/presentation, dosages & suggested regimens, baseline investigations, considerations & monitoring, contraindications, cautions, important drug interactions, adverse effects & their management, use in special situations, and essential patient information of Cyclophosphamide. Cyclophosphamide is an antineoplastic drug from the nitrogen mustard group of alkylating agents, which also include melphalan and chlorambucil. Cyclophosphamide is converted in the liver to active metabolites, such as phosphoramide mustard and toxic compounds by specific cytochrome P450 isoenzymes. The main use of cyclophosphamide is in combination with other agents in the treatment of a wide range of lymphomas, leukaemias and solid tumours. Cyclophosphamide is commonly used in conjunction with systemic corticosteroids. Cyclophosphamide should be given early in the day and a high fluid intake maintained throughout the day to encourage frequent bladder voiding. Cyclophosphamide is a known teratogen and should not be used in pregnancy except in life-threatening situations.
