ABSTRACT
When analytes lack an ultraviolet (UV) chromophore, alternative detection methods are necessary for high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), and supercritical fluid chromatography (SFC). Common alternatives to UV detection include refractive index (RI), mass spectrometry (MS), and aerosol-based detection. Both RI and MS have a few major drawbacks where aerosol-based detection is more appropriate. RI detectors are known to be generally unreliable, are incompatible with gradient elution, and suffer from poor sensitivity [1]. MS detectors are primarily limited by their ability to ionize the analyte, are expensive, often require a skilled operator, are frequently susceptible to matrix
1.1 Introduction ......................................................................................................1 1.2 Background and History ...................................................................................2 1.3 Types of Aerosol-Based Detectors ...................................................................3
