ABSTRACT

Cryogel beads, monolithic composites, bioseparation, microchannel liquid flow focusing

4.4.1.5 Mass Transfer Coefficient .................................................. 132 4.4.1.6 Adsorption Equilibrium Equation ..................................... 132

4.4.2 Numerical Solution of the Model ..................................................... 132 4.5 Applications of Cryogel Beads and Composite Cryogels ............................. 135 4.6 Conclusions ................................................................................................... 135 Acknowledgements ................................................................................................ 136 List of Abbreviations .............................................................................................. 136 References .............................................................................................................. 137

Cryogels are porous cross-linked polymers prepared by cryo-polymerization of an aqueous solution containing gel-forming reagents under freezing conditions. These interesting materials have micron-scale supermacropores and thus high porosity and permeability. Due to their intrinsic properties, cryogels have been suggested as new chromatographic adsorbents, immobilization matrices, cell scaffolds and drug delivery carriers for applications in the biotechnological, biomedical, pharmaceutical and even bioremediation fields (Gun’ko et al., 2013; Kirsebom et al., 2011; Kuyukina et al., 2013; Lozinsky, 2002, 2008; Lozinsky et al., 2003; Mattiasson et al., 2010; Plieva et al., 2007, 2008, 2011).