ABSTRACT
Abstract ................................................................................................. 336 22.1 Introduction .................................................................................. 336 22.2 Experimental ................................................................................ 337 22.2.1 Solid-Phase Modifiers .................................................... 337 22.2.2 Gels ................................................................................ 338 22.2.3 Thermal Effects .............................................................. 338 22.2.4 Cavitational Effects of Ultrasound Field ....................... 339 22.2.5 In Vitro Experiments ...................................................... 339 22.2.6 Electron Microscopy ...................................................... 340 22.2.7 In Vivo Experiments ...................................................... 340 22.3 Results .......................................................................................... 340 22.3.1 Modification of Hydrogels ............................................. 340 22.3.2 Thermal Effects .............................................................. 342 22.3.3 Cavitational Effects ........................................................ 343 22.3.4 Experiments in Vitro ...................................................... 344 22.3.5 Experiments in Vivo ....................................................... 345 22.4 Conclusion ................................................................................... 346 Keywords .............................................................................................. 347 References ............................................................................................. 347
ABSTRACT
In this chapter, the author’s views on the use of solid inclusions in biological structures as “concentrators” of acoustic energy for ultrasound treatment of cancer (solid-phase sonosensitization) are presented. Particular attention is drawn to the possibility of synthesis of these inclusions directly in the tumor. The validity of the hypothesis of solid-phase sonosensitization is confirmed in experiments on model systems and animals.
