ABSTRACT
The process of distribution refers to the movement or temporary storage of a drug once introduced to the body fluids. Drugs that are absorbed circulate to areas of the body where there is blood flow. Most drugs have target organs or tissues that preferentially take up or release drugs at varying rates. In general, organs with higher blood flow (i.e., heart, brain, kidneys) tend to accumulate drugs more rapidly.1 As the dose of a given drug increases, so does the concentration. When given by most routes, with the exception of intravenously administered drugs, several semipermeable cell membranes must be traversed by the processes of diffusion or active transport before a drug reaches the intended site of action.
