Signal Transduction Pathways That Regulate Mitochondrial Gene Expression

The limited encoding capacity of mtDNA necessitates knowledge of the nuclear origin of regulatory factors governing mitochondrial gene expressions. Here, we review the nuclear factors that control the transcription of genes involved in mitochondrial and nuclear regulation of mitochondrial functions. We focus on key nuclear factors and cofactors and their regulation by signal transduction pathways. These include nuclear respiratory factors (NRF) and estrogen

Abstract .................................................................................................................... 45 Transcriptional Networks That Control Mitochondrial Gene Transcription ............46