ABSTRACT
The anogenital area is susceptible to contact dermatitis due to intrinsic and extrinsic properties. Similar to the eyelid region, the anogenital region is intrinsically prone to irritation and sensitization. The anogenital region differs from other regions in that there is also a high degree of friction, heat, and moisture. Data collected by the North American Contact Dermatitis Group has been reviewed with regard to patients with anogenital dermatitis who were referred for patch testing. A high index of suspicion is required for the possibility of contact dermatitis medicamentosa in the anogenital region, especially in the setting of a dermatitis that is not responding as expected to conventional therapies. The vulvar region is susceptible to the same factors as the general anogenital region. Allergic contact dermatitis (ACD) of the vulva needs to be considered in vulvar dermatoses refractory to treatment. The foreskin may facilitate the retention and absorption of allergens and eventually play a role in the development of ACD.
