ABSTRACT
Acute pancreatitis (AP) is an acute inflammation process of the pancreas with variable involvement of other tissue or remote organ systems ranging from a mild, self-limited course requiring only brief hospitalization to a rapidly progressive, fulminant illness resulting in the multiple organ dysfunction syndromes with or without accompanying sepsis. Severe acute pancreatitis (SAP) is a common disease with emergency situation involving organ failure and/or local complications such as necrosis, abscess, or pseudocysts having mortality of up to 30 percent. Despite improvements in intensive care treatment during the past few decades, the rate of death from SAP has not significantly declined [1]. The pathogenesis of acute pancreatitis relates to inappropriate conversion of trypsinogen to trypsin and a lack of prompt elimination of active trypsin inside pancreas [2].
