ABSTRACT
Obesity is a chronic condition of nutrients accumulation [1,2] in which excess energy aggregates in the form of fat mass [3]. Based on the thrifty genotype hypothesis [4], since metabolic efficiency is raised in negative energy states, important interactions between gene and obesogenic environment (including food abundance and low physical activity [5]) result in improper metabolic programming and epigenic change in utero; hence in this condition obesity is an inevitable outcome [6]. Fat mass distribution specifically visceral distribution, produces toxic milieu by initiating metabolic and inflammatory cascade, which is followed by endocrine, cardiovascular and malignant events. The risk of mortality rises synergistically with increase in BMI over than 30 kg/m2 [1].
