ABSTRACT
Toxic Principle and Mechanism of Action A variety of toxic isoquinoline alkaloids including allocrytapine, berberine, chelidonine, coptisine, protopine, and sanguinarine are found in the sap and other parts of the plant.1-3 These compounds are bitter tasting, and have spasmolytic effects on the GABA receptors.2 Primary effects appear to be on the gastrointestinal system with signs of constipation followed by excessive salivation, frequent urination and diarrhea. Affected animals are depressed and drowsy, and may develop seizures in severe cases. The orange latex is irritating to the skin and has been used to treat skin warts. In Europe and China the plant has long been considered an herbal medicine, but greater celandine should be used with caution as it will cause cholestatic hepatitis in people.4
