ABSTRACT
Central Diabetes Insipidus (CDI) Central diabetes insipidus results from the destruction of ADH production sites in the hypothalamus (the supraoptic and paraventricular nuclei), loss of major axons that carry ADH to its storage sites in the posterior pituitary, or disruption of the ability to release stored ADH (Part B). Animals with CDI reportedly have difficulty increasing their urine osmolarity, even with water restriction. Consequently, the specific gravity of their urine can remain hyposthenuric ( 1.006).
