ABSTRACT

Detection of antibodies against parathyroid tissue in human patients has led to speculation that some forms of primary hypoparathyroidism in animals may be caused by autoimmune processes.

Pseudohypoparathyroidism Pseudohypoparathyroidism is a rare disorder characterized by target tissue resistance to PTH. Although it has been described in humans, reports of domestic animals with this specific disease are lacking. Symptoms in humans are hypocalcemia, increased serum concentrations of PTH (a form of secondary hyperparathyroidism), and a variety of skeletal development defects. Renal tubular resistance to PTH causes hypercalciuria and diminished phosphaturia.