ABSTRACT
Although ACTH plays an important permissive role in maintaining biosynthetic stability and responsiveness of the zona glomerulosa to other controlling factors (e.g., increased serum K+ and the angiotensins; Part A), it plays a minor facilitory role in aldosterone release. The major target sites for aldosterone are the distal convoluted tubules and cortical collecting ducts of the kidneys, where it facilitates Na+ reabsorption and K+ and H+ secretion.
